Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties

Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties Научная публикация

Журнал

FEBS Letters
ISSN: 0014-5793 , E-ISSN: 1873-3468

Вых. Данные

Год: 1993, Том: 329, Номер: 1-2, Страницы: 21-24 Страниц : 4 DOI: 10.1016/0014-5793(93)80184-V

Авторы

Судьина Галина Федоровна , Мирзоева Ольга Константиновна , Пушкарева М А , Korshunova G.A. , Sumbatyan N.V. , Варфоломеев Сергей Дмитриевич

Организации

1	Lomonosov Moscow State University

Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid phenethyl ester also exhibits antioxidant properties. At a concentration of 10 μM, it completely blocks production of reactive oxygen species in human neutrophils and the xanthine/xanthine oxidase system.

Sudʹina G.F. , Mirzoeva O.K. , Pushkareva M.A. , Korshunova G.A. , Sumbatyan N.V. , Varfolomeev S.D.
Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties
FEBS Letters. 1993. V.329. N1-2. P.21-24. DOI: 10.1016/0014-5793(93)80184-V Scopus OpenAlex

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