Kinetic Features of Elongation of Nucleic Acids as a Multistep Sequential Enzymatic Reaction

Kinetic Features of Elongation of Nucleic Acids as a Multistep Sequential Enzymatic Reaction Научная публикация

Журнал

Kinetics and Catalysis
ISSN: 0023-1584 , E-ISSN: 1608-3210

Вых. Данные

Год: 2023, Том: 64, Номер: 2, Страницы: 161-167 Страниц : 7 DOI: 10.1134/s0023158423020040

Авторы

Lukovenkov A.V. ¹ , Bykov V.I. ^1,2 , Varfolomeev S.D. ^1,2,3

Организации

1	Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia
2	Institute of Physicochemical Foundations of Functioning of Neural Networks and Artificial Intelligence, Lomonosov Moscow State University, 119192, Moscow, Russia
3	Chair of Chemical Enzymology, Chemical Faculty, Lomonosov Moscow State University, 119192, Moscow, Russia

The kinetics of elongation of nucleic acids as a multistep sequential reaction forming a cycle was studied. A mathematically rigorous proof was given for the empirical formulas used to estimate the elongation time as a function of the length of the nucleotide chain. Estimates of the characteristic elongation time for typical chain lengths were proposed, including for the novel coronavirus (SARS-CoV-2). The stability of the elongation kinetics was investigated, and it was determined that, at typical chain lengths, increasing-amplitude unstable oscillating components appear along with the main exponential component.

Lukovenkov A.V. , Bykov V.I. , Varfolomeev S.D.
Kinetic Features of Elongation of Nucleic Acids as a Multistep Sequential Enzymatic Reaction
Kinetics and Catalysis. 2023. V.64. N2. P.161-167. DOI: 10.1134/s0023158423020040 WOS Scopus РИНЦ CAPlusCA OpenAlex

Луковенков А.В. , Быков В.И. , Варфоломеев С.Д.
Кинетические особенности элонгации нуклеиновых кислот как многостадийной последовательной ферментативной реакции
Кинетика и катализ. 2023. Т.64. №2. С.181-188. DOI: 10.31857/S0453881123020041 РИНЦ OpenAlex

Поступила в редакцию:	10 окт. 2022 г.
Принята к публикации:	8 нояб. 2022 г.
Опубликована в печати:	1 апр. 2023 г.
Опубликована online:	16 июн. 2023 г.

Web of science:	WOS:001011416800005
Scopus:	2-s2.0-85162048820
РИНЦ:	61757034
Chemical Abstracts:	2023:1256895
Chemical Abstracts (print):	183:167574
OpenAlex:	W4380760336