Physicochemical Properties of the Supramolecular Complex of Artesunate with Sodium Glycyrrhizinate and Its Opisthorchicidal Activity in vitro against the Trematode Opisthorchis felineus

Physicochemical Properties of the Supramolecular Complex of Artesunate with Sodium Glycyrrhizinate and Its Opisthorchicidal Activity in vitro against the Trematode Opisthorchis felineus Научная публикация

Журнал

Chemistry for Sustainable Development
ISSN: 1817-1818

Вых. Данные

Год: 2024, Том: 32, Номер: 5, Страницы: 627-635 Страниц : 9 DOI: 10.15372/CSD2024597

Авторы

Ponomarev D.V. ¹ , Lvova M.N. ¹ , Avgustinovich D.F. ^1,2 , Meteleva E.S. ² , Evseenko V.I. ² , Selyutina O.Yu. ^2,3 , Polyakov N.E. ^2,3 , Dushkin A.V. ^2,4

Организации

1	Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2	Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
3	Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
4	Zhejiang University of Technology, Hangzhou, China

Using the mechanochemical method, supramolecular compositions of a potential anthelmintic, artesunate (ARS) with sodium glycyrrhizinate (Na2GA), were obtained in different mass ratios of the components included in ARS-Na2GA complex (1 : 5, 1 : 10, and 1 : 20). The formation of an inclusion complex of ARS with Na2GA micelles was confirmed by NMR relaxation and the nuclear Overhauser effect (NOESY). It has been established that the ARS-Na2GA complex (1 : 10) has optimal physicochemical properties for further biological studies on the helminths Opisthorchis felineus , which cause opisthorchiasis in humans and animals. Experiments in vitro showed that ARS-Na2GA complex (1 : 10) had a more pronounced inhibition of motility both in invasive individuals of O. felineus (metacercariae) and in adult trematodes (maritae), compared with pure ARS, and even at low concentrations (0.1-10 µg/mL) for maritae. Despite the fact that the dose of ARS in the composition of ARS-Na2GA (1:10) was 11 times lower, the efficiency coefficient (IC50) declined 2.4-fold (for metacercariae) and 1.45-fold (for maritae) with respect to pure ARS. The results obtained indicate the availability of using the new complex for further studies on O. felineus -infected animals.

Ponomarev D.V. , Lvova M.N. , Avgustinovich D.F. , Meteleva E.S. , Evseenko V.I. , Selyutina O.Y. , Polyakov N.E. , Dushkin A.V.
Physicochemical Properties of the Supramolecular Complex of Artesunate with Sodium Glycyrrhizinate and Its Opisthorchicidal Activity in vitro against the Trematode Opisthorchis felineus
Chemistry for Sustainable Development. 2024. V.32. N5. P.627-635. DOI: 10.15372/CSD2024597 WOS РИНЦ OpenAlex

Пономарёв Д.В. , Львова М.Н. , Августинович Д.Ф. , Метелева Е.С. , Евсеенко В.И. , Селютина О.Ю. , Поляков Н.Э. , Душкин А.В.
Физико-химические свойства супрамолекулярного комплекса артесуната с глицирризинатом натрия и его описторхицидная активность in vitro в отношении трематоды Opisthorchis felineus
Химия в интересах устойчивого развития. 2024. Т.32. №5. С.646-654. DOI: 10.15372/KhUR2024597 РИНЦ CAPlus OpenAlex

Поступила в редакцию:	21 мая 2024 г.
Принята к публикации:	30 авг. 2024 г.
Опубликована online:	16 янв. 2025 г.

Web of science:	WOS:001402751800001
РИНЦ:	79629425
OpenAlex:	W4408943899