Сocrystals of Betulin with Dicarboxylic Acids: Solid State Synthesis and Properties

Сocrystals of Betulin with Dicarboxylic Acids: Solid State Synthesis and Properties Научная публикация

Журнал

Chemistry for Sustainable Development
ISSN: 1817-1818

Вых. Данные

Год: 2024, Том: 32, Номер: 5, Страницы: 678-686 Страниц : 9 DOI: 10.15372/CSD2024603

Авторы

Shakhtshneider T.P. ¹ , Myz S.A. ¹ , Mikhailenko M.A. ¹ , Kuznetsova S.A. ²

Организации

1	Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2	Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science, Institute of Chemistry and Chemical Technology SB RAS, Krasnoyarsk, Russia

Cocrystals of betulin with dicarboxylic acids were obtained using mechanochemical treatment with the addition of small amounts of organic solvents. The formation of cocrystals was confirmed by powder X-ray diffraction, thermal analysis, and IR spectroscopy methods. The presence of a solvent, the optimal components ratio, and the duration of mechanical processing are important for the formation of cocrystals. In order to choose a solvent for preparing betulin cocrystals, the solvents of different polarity were compared. It has been shown that cocrystals are formed if solvents that can effectively dissolve dicarboxylic acid are used during mechanical processing. For comparison with the mechanochemical method, betulin cocrystals were obtained by heating a mixture of starting reagents. Morphological changes observed by scanning electron microscopy upon heating the reaction mixtures also indicate the formation of cocrystals. It has been shown that when cocrystals are dissolved in water, solutions with an increased concentration of betulin are formed, and an increase in the length of the aliphatic chain of the acid leads to a decrease in the rate of betulin release into the solution.

Shakhtshneider T.P. , Myz S.A. , Mikhailenko M.A. , Kuznetsova S.A.
Сocrystals of Betulin with Dicarboxylic Acids: Solid State Synthesis and Properties
Chemistry for Sustainable Development. 2024. V.32. N5. P.678-686. DOI: 10.15372/CSD2024603 WOS РИНЦ OpenAlex

Шахтшнейдер Т.П. , Мызь С.А. , Михайленко М.А. , Кузнецова С.А.
Смешанные кристаллы бетулина с дикарбоновыми кислотами: твердофазный синтез и физико-химические свойства
Химия в интересах устойчивого развития. 2024. Т.32. №5. С.698-707. DOI: 10.15372/KhUR2024603 РИНЦ CAPlus OpenAlex

Поступила в редакцию:	16 мая 2024 г.
Принята к публикации:	25 сент. 2024 г.
Опубликована online:	16 янв. 2025 г.

Web of science:	WOS:001402744200001
РИНЦ:	79629431
OpenAlex:	W4408944089