Role of Acetylcholinesterase in β-Amyloid Aggregation Studied by Accelerated Molecular Dynamics

Role of Acetylcholinesterase in β-Amyloid Aggregation Studied by Accelerated Molecular Dynamics Научная публикация

Журнал

BioNanoScience
ISSN: 2191-1630 , E-ISSN: 2191-1649

Вых. Данные

Год: 2016, Том: 7, Номер: 2, Страницы: 396-402 Страниц : 7 DOI: 10.1007/s12668-016-0375-x

Авторы

Lushchekina Sofya V. ¹ , Kots Ekaterina D. ¹ , Novichkova Dana A. ² , Petrov Konstantin A. ³ , Masson Patrick ⁴

Организации

1	Emanuel Institute of Biochemical Physics of Russian Academy of Sciences
2	Lomonosov Moscow State University
3	Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS
4	Kazan (Volga Region) Federal University

Mechanisms of Alzheimer’s disease development are still under investigation. It was shown that acetylcholinesterase promotes aggregation of β-amyloid. Accelerated molecular dynamics simulations were performed to investigate molecular mechanisms of this process. Results showed that Aβ is strongly attracted to the surface of acetylcholinesterase and forms stable complexes. It was hypothesized that acetylcholinesterase serves as a nucleation center for propagation of β-amyloid aggregation.

Lushchekina S.V. , Kots E.D. , Novichkova D.A. , Petrov K.A. , Masson P.
Role of Acetylcholinesterase in β-Amyloid Aggregation Studied by Accelerated Molecular Dynamics
BioNanoScience. 2016. V.7. N2. P.396-402. DOI: 10.1007/s12668-016-0375-x Scopus OpenAlex

Scopus:	2-s2.0-85019115416
OpenAlex:	W2551018908

БД	Цитирований
OpenAlex	30