Реферат: The rate constant of the reaction of 6-amino-5-hydroxy-2,3-dimethylpyrimidin-4(3H)-one (1) with peroxyl radicals was measured in a model system of radical chain oxidation of 1,4-dioxane. Oxidation of 1,4-dioxane with atmospheric oxygen was carried out at a temperature of 333 K. Oxygen uptake was monitored using a universal differential manometric setup. It was found that 6-amino-5-hydroxy-2,3-dimethylpyrimidin-4(3H)-one slowed down the rate of 1,4-dioxane oxidation. The effective rate constant of the interaction of the peroxyl radical of 1,4-dioxane with 6-amino-5-hydroxy-2,3-dimethylpyrimidin-4(3H)-one was found: fk7 = (6.2 ± 0.1) × 105 L mol–1 s–1. The stoichiometric inhibition coefficient f = 1.3 ± 0.1 was calculated from the slope of the dependence of the induction period length on the concentration of 6-amino-5-hydroxy-2,3-dimethylpyrimidin-4(3H)-one. The experimental data indicated that 6-amino-5-hydroxy-2,3-dimethylpyrimidin-4(3H)-one has antioxidant properties. It was assumed that the hydroxyl group –OH located in the 5-position of the ring was the site attacked by the peroxyl radical.

Библиографическая ссылка: Migranov A.R. , Yakupova L.R. , Safiullin R.L. , Grabovsky S.A.
6-Amino-5-hydroxy-2,3-dimethylpyrimidin-4(3H)-one as an Oxidation Inhibitor
Kinetics and Catalysis. 2025. V.66. N3. P.280-285. DOI: 10.1134/s0023158424602420 WOS Scopus CAPlus OpenAlex

Даты:

Поступила в редакцию:	17 окт. 2024 г.
Принята к публикации:	27 мая 2025 г.
Опубликована online:	4 сент. 2025 г.

Идентификаторы БД:

Web of science:	WOS:001566661700006
Scopus:	2-s2.0-105015141189
Chemical Abstracts:	2025:2208973
OpenAlex:	W4414004147

Альметрики: