Novel fragment-like inhibitors of EphA2 obtained by experimental screening and modelling

Novel fragment-like inhibitors of EphA2 obtained by experimental screening and modelling Научная публикация

Журнал

Mendeleev Communications
ISSN: 0959-9436

Вых. Данные

Год: 2010, Том: 20, Номер: 5, Страницы: 263-265 Страниц : 3 DOI: 10.1016/j.mencom.2010.09.007

Авторы

Stroylov Viktor S. ¹ , Rakitina Tatiana V. ^2,3 , Novikov Fedor N. ¹ , Stroganov Oleg V. ^1,4 , Chilov Ghermes G. ^1,4 , Lipkin Aleksey V. ^3,5

Организации

1	MolTech Ltd., 119992 Moscow, Russian Federation
2	M. M. Shemyakin–Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russian Federation
3	Russian Research Centre 'Kurchatov Institute', 123182 Moscow, Russian Federation
4	N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation
5	A. V. Shubnikov Institute of Crystallography, Russian Academy of Sciences, 119333 Moscow, Russian Federation

A set of novel fragment-like catechol derivatives were identified as EphA2 inhibitors and were further profiled against a panel of 19 tyrosine kinases. In addition to EphA2, the recovered hits were active against EGFR, FGFR1, FGFR2, Abl and PDGFR-a, and according to molecular modelling studies catechol moiety was capable of forming two or more correlated hydrogen bonds with the kinase hinge region, suggesting prospects of its further optimization as an EphA2 inhibitor.

Stroylov V.S. , Rakitina T.V. , Novikov F.N. , Stroganov O.V. , Chilov G.G. , Lipkin A.V.
Novel fragment-like inhibitors of EphA2 obtained by experimental screening and modelling
Mendeleev Communications. 2010. V.20. N5. P.263-265. DOI: 10.1016/j.mencom.2010.09.007 WOS Scopus OpenAlex

Web of science:	WOS:000283695500007
Scopus:	2-s2.0-77958053207
OpenAlex:	W2012175088

БД	Цитирований
OpenAlex	10
Scopus	11