Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications Обзор

Журнал

Nanomaterials
ISSN: 2079-4991

Вых. Данные

Год: 2021, Том: 11, Номер: 9, Номер статьи : 2255, Страниц : 22 DOI: 10.3390/nano11092255

Авторы

Golovin Yuri I. ^1,2 , Golovin Dmitry Yu. ¹ , Vlasova Ksenia Yu. ² , Veselov Maxim M. ² , Usvaliev Azizbek D. ² , Kabanov Alexander V. ^2,3 , Klyachko Natalia L. ^1,2,3

Организации

1	Institute "Nanotechnology and Nanomaterials", G.R. Derzhavin Tambov State University, 392000 Tambov, Russia
2	Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia
3	Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

The review discusses the theoretical, experimental and toxicological aspects of the prospective biomedical application of functionalized magnetic nanoparticles (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). In this approach, known as nano-magnetomechanical activation (NMMA), the MNPs are used as mediators that localize and apply force to such target biomolecular structures as enzyme molecules, transport vesicles, cell organelles, etc., without significant heating. It is shown that NMMA can become a biophysical platform for a family of therapy methods including the addressed delivery and controlled release of therapeutic agents from transport nanomodules, as well as selective molecular nanoscale localized drugless nanomechanical impacts. It is characterized by low system biochemical and electromagnetic toxicity. A technique of 3D scanning of the NMMA region with the size of several mm to several cm over object internals has been described.

Golovin Y.I. , Golovin D.Y. , Vlasova K.Y. , Veselov M.M. , Usvaliev A.D. , Kabanov A.V. , Klyachko N.L.
Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications
Nanomaterials. 2021. V.11. N9. 2255 :1-22. DOI: 10.3390/nano11092255 WOS

Web of science:

WOS:000701657200001